NEET PG DENTAL EXAM

Detailed explanation-1: -A mast cell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.

Detailed explanation-2: -Mast cell granules are particularly rich in proteases. These proteases are the major proteins present in mast cells; representing up to 50% of the total protein content of the granule.

Detailed explanation-3: -Heparin, well known anticoagulant, can also modulate inflammatory and immunologic processes. Some investigators suggest that heparin inhibits mast cell degranulation. Mast cells play very important role in early phase of asthmatic reaction, releasing many proinflammatory mediators including histamine.