NEET PG DENTAL EXAM

Detailed explanation-1: -When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen. It can also create a build-up of mucus in the airways, which become narrower.

Detailed explanation-2: -Mast cells initiate innate immune responses to pathogens In addition to recruiting inflammatory cells, MCs can also directly kill opsonized bacteria.

Detailed explanation-3: -Most commonly the receptors on the mast cells are TLRs and receptors for complement. Once the antigen binds to the receptors on the mast cell, it causes the release of inflammatory mediators, which helps to eliminate the pathogen that activated it.