NEET PG DENTAL EXAM

Detailed explanation-1: -They contain chemicals such as histamine, heparin, cytokines, and growth factors. They release these chemicals during allergic reactions and certain immune responses. These chemicals have many effects, including the widening of blood vessels and angiogenesis.

Detailed explanation-2: -Heparin, well known anticoagulant, can also modulate inflammatory and immunologic processes. Some investigators suggest that heparin inhibits mast cell degranulation. Mast cells play very important role in early phase of asthmatic reaction, releasing many proinflammatory mediators including histamine.

Detailed explanation-3: -In addition to heparin, the granules contain histamine and other inflammatory mediators. The cell is localized perivascularly in the loose connective tissue. The mast cell secretes histamine by exocytosis when it is stimulated immunologically by binding of a specific antigen to IgE molecules in the cell membrane.