NEET PG DENTAL EXAM

Detailed explanation-1: -Roughly, 80% of bilirubin is made from the breakdown of hemoglobin in senescent red blood cells, and prematurely destroyed erythroid cells in the bone marrow. The remainder originates from the turnover of various heme-containing proteins found in other tissues, primarily the liver and muscles.

Detailed explanation-2: -The bile pigments are formed by decomposition of the porphyrin ring and contain a chain of four pyrrole rings. Bilirubin, for example, the brownish yellow pigment that gives feces its characteristic colour, is the end product of the breakdown of heme from destroyed red blood cells.

Detailed explanation-3: -The bile pigments derived from the hemoglobin of worn-out red cells and other sources amounts to about 250 mg. per day in a 70 kg. man. The mechanisms of formation and degradation of hemoglobin and the fate of bile pigments are discussed.