NEET PG DENTAL EXAM

Detailed explanation-1: -Microglia are currently considered to be the major phagocytes in the brain parenchyma, and these cells phagocytose a variety of materials, including dead cell debris, abnormally aggregated proteins, and, interestingly, the functional synapses of living neurons.

Detailed explanation-2: -Microglia, the brain’s professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons-a process that we have termed phagoptosis.

Detailed explanation-3: -Microglia are the brain’s main phagocytes (cells capable of engulfing and digesting large extracellular particles), and protect the brain by phagocytosing bacteria, aggregated proteins and cellular debris (Galloway et al., 2019; Vilalta & Brown, 2018; Wolf et al., 2017).