NEET PG DENTAL EXAM

Detailed explanation-1: -Creatinine is a by-product of muscle metabolism in which creatine in the muscle is converted nonenzymatically to creatinine. Because the total body content of creatine is fairly constant, there is a continual production of creatinine and a continual excretion of it in the urine.

Detailed explanation-2: -Creatinine is a break-down product of creatine phosphate in muscle tissue. It is usually produced at a fairly constant rate. Creatinine is cleared by the kidneys with minimal tubular reabsorption. Creatinine accumulates in the blood when GFR decreases in the setting of renal dysfunction.