NEET PG DENTAL EXAM

Detailed explanation-1: -Starting at the kidneys, PTH stimulates the production of 1alpha-hydroxylase in the proximal convoluted tubule. This enzyme, 1alpha-hydroxylase, is required to catalyze the synthesis of active vitamin D-1, 25-dihydroxycholecalciferol from the inactive form 25-hydroxycholecalciferol.

Detailed explanation-2: -Calcitriol is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis.

Detailed explanation-3: -Vitamin D is converted enzymatically in the liver to 25-hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then in the kidney to 1, 25-dihydroxyvitamin D, the active form of vitamin D.

Detailed explanation-4: -Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally.