NEET PG DENTAL EXAM

Detailed explanation-1: -Most of the glucose entering the tubular system is reabsorbed along the nephron segments, primarily in the proximal tubule, such that urine is almost free of glucose. This is different in diabetes, where the filtered glucose exceeds the transport capacity of the tubular system for glucose and glucosuria occurs.

Detailed explanation-2: -SGLT1, which are found in the straight section of the proximal tubule (S3), are responsible for approximately 10% of glucose reabsorption. The other 90% of filtered glucose is reabsorbed through by SGLT2, which are located in the convoluted section on the proximal tubule (S1)[5] [Table 1].

Detailed explanation-3: -The kidneys reabsorb filtered glucose through the sodium‐glucose cotransporters sodium‐glucose cotransporter (SGLT) 1 and SGLT2, which are localized on the brush border membrane of the early proximal tubule with immune detection of their expression in the tubularized Bowman capsule.