PSYCHOLOGY OF EMOTIONS

Detailed explanation-1: -If cocaine is present, it attaches to the dopamine transporter and blocks the normal recycling process, resulting in a buildup of dopamine in the synapse, which contributes to the pleasurable effects of cocaine.

Detailed explanation-2: -It has been demonstrated that cocaine may inhibit the transport of dopamine through both blocking the initial DAT-dopamine binding and reducing the kinetic turnover of the transporter following the DAT-dopamine binding.

Detailed explanation-3: -Cocaine inhibits the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT).

Detailed explanation-4: -Explain why cocaine is able to bind to the dopamine transporter. Dopamine and cocaine have similar shapes so cocaine can fit transporter. Serotonin is a neurotransmitter released in some synapses in the brain. It is transported back out of the synaptic gap by a transport protein in the pre-synaptic membrane.