PSYCHOLOGY OF EMOTIONS

Detailed explanation-1: -As mentioned previously, opioids in the CNS exert their analgesic effect by increasing dopamine release by disinhibiting GABA’s effect on dopaminergic neurons.

Detailed explanation-2: -Endorphins boost the release of dopamine in your body. Dopamine is another neurotransmitter. The release of dopamine affects your mood. People with a lack of endorphins may show signs of depression.

Detailed explanation-3: -One of the brain circuits that is activated by opioids is the mesolimbic (midbrain) reward system. This system generates signals in a part of the brain called the ventral tegmental area (VTA) that result in the release of the chemical dopamine (DA) in another part of the brain, the nucleus accumbens (NAc) (Figure 1).

Detailed explanation-4: -Opioids trigger the release of endorphins, your brain’s feel-good neurotransmitters. Endorphins muffle your perception of pain and boost feelings of pleasure, creating a temporary but powerful sense of well-being.

Detailed explanation-5: -Beta-endorphins are one of five groups of naturally occurring opioid peptides that modulate pain and dyspnea. In response to noxious and stressful stimuli, the pituitary gland releases beta-endorphins into the circulation, whereas the brain elaborates endogenous opioids into the cerebrospinal fluid.