THORAX ABDOMEN AND PELVIS

Detailed explanation-1: -Some drugs commonly used for colorectal cancer include: 5-Fluorouracil (5-FU) Capecitabine (Xeloda), a pill that is changed into 5-FU once it gets to the tumor. Irinotecan (Camptosar)

Detailed explanation-2: -Fluorouracil is used in combination with other medications to treat certain types of breast cancer after surgery to remove the tumor or radiation therapy. Fluorouracil is also used to treat cancer of the pancreas and stomach cancer.

Detailed explanation-3: -5‐Fluorouracil (5‐FU), a synthetic fluorinated pyrimidine analog requiring intracellular conversion into active metabolites, is the main chemotherapy used when colorectal cancer is at an advanced stage or at high risk of recurrence. However, resistance to this treatment exists, explaining a low 5‐year survival rate.

Detailed explanation-4: -The most commonly used chemotherapy for colorectal cancer is 5-fluorouracil (5FU) [2] but recurrence after 5-FU therapy is unfortunately common and potentially linked to p53 mediated WNT/-catenin signaling leading to cancer stem cell enrichment [3].