MEDICAL
HEART AND PERICARDIUM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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If this cation has elevated levels in the blood it increases Heart Rate and Contractility?
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Na
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K
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Ca
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S
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Explanation:
Detailed explanation-1: -Calcium plays two pivotal roles in cardiac excitation-contraction (E-C) coupling. Ca2+ drives myofilament activation and carries or regulates ionic currents that are responsible for normal electrical rhythms2 as well as life-threatening arrhythmias.
Detailed explanation-2: -Activation of these proteins by PKA phosphorylation increases systolic SR calcium release which causes both increased cardiac contraction and output.
Detailed explanation-3: -Intracellular calcium concentrations increase when the sarcoplasmic reticulum releases calcium ions. Contraction is triggered when these calcium ions bind to the protein complex troponin, uncovering the active-binding sites on actin.
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