MEDICAL
LIVER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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using ethanol dehydrogenase
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converted into hydrophobic substances
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converted into hydrophilic substances
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converted into urea
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Detailed explanation-1: -The amino acid is transaminated to produce a molecule of glutamate. Glutamate is the one amino acid that undergoes oxidative deamination to liberate free ammonia for the synthesis of urea. Once free ammonia is formed in peripheral tissues, it must be transferred to the liver for the conversation to urea.
Detailed explanation-2: -Ammonia detoxification in the liver occurs mainly in periportal hepatocytes in the urea cycle (ornithine cycle), leading to urea formation. Urea is subsequently released into the hepatic veins and then excreted in the urine. Hepatic urea synthesis is a low affinity, high capacity detoxification system (Meijer et al.
Detailed explanation-3: -In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxylase (PC) and glutamate dehydrogenase (GDH).