MEDICAL
LIVER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following are true of a sinusoid?I. it is involved in the exchange of materials between hepatocytes and bloodII. Kupffer cells contain microvilli for faster exchangeIII. blood from the hepatic artery and hepatic portal vein mixes within it
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I and II only
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I and III only
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II and III only
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I, II and III
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Explanation:
Detailed explanation-1: -Although their main function is phagocytosis and defence of the liver against bacteria, endotoxaemia and viral infections, they also fulfil other important roles. They will phagocytose and partially degrade bacterial antigens before handing them on to the hepatocytes for excretion into the bile.
Detailed explanation-2: -Liver sinusoids are thought to be the main site of blood flow regulation within the liver. LSECs respond to changes in portal blood flow and pressure, and even produce vasoactive molecules to signal to HSCs and eventually regulate the sinusoidal diameter.
Detailed explanation-3: -The Disse space lies between hepatocytes and the sinusoids and is also referred to as the perisinusoidal space.
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