MEDICAL
PANCREAS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A 5-year-old girl presents with yellow skin and sclerae.The parents believe that she recently swallowed a bottleof acetaminophen tablets. A liver biopsy reveals hepaticnecrosis. Which of the following enzymes metabolizedacetaminophen and generated toxic metabolites in theliver of this young patient?
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Catalase
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Cytochrome P450
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Myeloperoxidase
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NADPH oxidase
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Superoxide dismutase
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Explanation:
Detailed explanation-1: -Glucuronidation is the main pathway of acetaminophen metabolism, followed by sulfation and a minor contribution from the oxidation route. Oxidation by CYP isozymes yields a reactive metabolite NAPQI that is detoxified by the glutathione pathway.
Detailed explanation-2: -Acetaminophen metabolism-UpToDate. At therapeutic doses, 90 percent of acetaminophen is metabolized in the liver to sulfate and glucuronide conjugates that are then excreted in the urine.
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