THORAX ABDOMEN AND PELVIS

MEDICAL

PANCREAS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A 69-year-old man is brought to the emergency room ina disoriented state. Physical examination reveals an odorof alcohol, as well as jaundice and ascites. Serum levels ofaspartate aminotransferase (AST), alanine aminotransferase(ALT), alkaline phosphatase, and bilirubin are all elevated.Increased serum levels of alkaline phosphatase are an indi-cator of injury to which of the following tissues/structures?
A
Bile ducts
B
Centrilobular hepatocytes
C
Islets of Langerhans
D
Pancreatic exocrine acini
E
Periportal hepatocytes
Explanation: 

Detailed explanation-1: -In general, high levels of ALT may be a sign of liver damage from hepatitis, infection, cirrhosis, liver cancer, or other liver diseases. The damage may also be from a lack of blood flow to the liver or certain medicines or poisons.

Detailed explanation-2: -Ascites is a buildup of fluid in your abdomen. It often occurs as a result of cirrhosis, a liver disease. Talk to your healthcare provider if you have cirrhosis and notice you’re gaining weight very quickly. Your provider will talk to you about treatments, which often include a low-salt diet.

Detailed explanation-3: -One of the main reasons why acute alcoholic hepatitis has a relatively high AST/ALT ratio is because patients are often tested within 24 h of alcohol exposure so the faster clearance of AST (t½ =18 h) hasn’t had time to take effect.

There is 1 question to complete.