MEDICAL
PANCREAS
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Trypsinogen is converted into its active form, trypsin, by
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cholecystokinin
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secretin
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enterokinase
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lipase
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Explanation:
Detailed explanation-1: -Mold kinase transforms trypsinogen to trypsin only in an acid medium. It differs thus from enterokinase and trypsin which activate trypsinogen best in a slightly alkaline medium.
Detailed explanation-2: -Once trypsinogen is released into the lumen of the small intestine, enterokinase produced by the duodenal mucosa converts trypsinogen into an active form, trypsin.
Detailed explanation-3: -Enterokinase is a protease of the intestinal brush border that specifically cleaves the acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates a cascade of proteolytic reactions leading to the activation of many pancreatic zymogens.
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