MEDICAL
PLEURA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What type of tumor is more frequent in the alteration of the RAS gene?
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small cell carcinoma
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squamous cell carcinoma
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hamartroma
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Lymphadenopathy
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Explanation:
Detailed explanation-1: -Although pancreatic adenocarcinomas are not among the most frequently detected tumors worldwide, they are among the most aggressive and with worst prognosis/outcome in humans. These tumors harbor the highest reported incidence of ras mutations among all human cancers.
Detailed explanation-2: -Of the 3 RAS genes (KRAS, NRAS, and HRAS), KRAS is most commonly mutated in pancreatic, colorectal, and lung adenocarcinomas, whereas NRAS and HRAS mutations are mostly found in selected hematologic malignancies, melanomas and thyroid cancers.
Detailed explanation-3: -Amplification of 3q26 is one of the most frequently reported alterations in squamous cell lung cancer.
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