THORAX ABDOMEN AND PELVIS

Detailed explanation-1: -Mutations in several tumor suppressor genes and receptor tyrosine kinases (RTKs) deregulate cell growth and survival by increasing mammalian target of rapamycin (mTOR) signaling. This convergence on mTOR is well-illustrated in brain tumors (gliomas) in which mutations lead to mTOR-dependent growth deregulation.

Detailed explanation-2: -In summary, individuals with NF1 are predisposed to a variety of brain tumors such as optic pathway gliomas, brainstem gliomas, and glioblastomas that tend to act more indolently than their sporadic counterparts.

Detailed explanation-3: -Mutations in the NF1 gene lead to the production of a nonfunctional version of neurofibromin that cannot regulate cell growth and division. As a result, tumors such as neurofibromas can form along nerves throughout the body.