MEDICAL
SPLEEN
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
production of antibody
|
|
|
control of red cell integrity
|
|
|
extramedullary haematopoiesis
|
|
|
sequestration of formed elements
|
Detailed explanation-1: -Splenomegaly is one of the major clinical manifestations of MF and is directly linked to splenic extramedullary hematopoiesis (EMH). EMH is associated with abnormal trafficking patterns of clonal hematopoietic cells due to the dysregulated bone marrow (BM) microenvironment leading to progressive splenomegaly.
Detailed explanation-2: -The most common causes of splenomegaly include infections, certain cancers, and portal hypertension, which mostly results from liver diseases like cirrhosis. Splenomegaly is considered a serious condition with potential life-threatening consequences, such as significant blood loss due to splenic rupture.
Detailed explanation-3: -Splenomegaly can be caused by any of the following: Infections. Liver diseases. Blood diseases.