THORAX ABDOMEN AND PELVIS

MEDICAL

SPLEEN

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Which of the following conditions can result in functional hyposplenism?

A	chronic myeloid leukaemia
B	sickle cell anaemia
C	hairy cell leukaemia
D	Gaucher’s disease

Explanation:

Detailed explanation-1: -In many benign hematologic disorders, for example, functional asplenia is caused by persistent and recurrent hyper sequestration of red blood cells (RBCs) leading to RBC entrapment. This entrapment leads to splenic enlargement and then later atrophy.

Detailed explanation-2: -Hyposplenism can be caused by several conditions, including haematological, infectious, autoimmune and gastrointestinal disorders. Anatomical disruption of the spleen and depletion of immune cells, especially IgM memory B cells, seem to be predominantly responsible for the clinical manifestations.

Detailed explanation-3: -Acute leukemia. Chronic lymphocytic leukemia. Hematopoietic stem cell transplantation (particularly if associated graft versus host disease) Lymphoma. Mastocytosis. Myeloproliferative neoplasm. Sickle cell disease (eg, HbSS, HbSC, HbS-beta thalassemia) Thalassemia.

There is 1 question to complete.