THORAX ABDOMEN AND PELVIS

Detailed explanation-1: -Mast cells are also important in the pathophysiology of asthma. Activated mast cells release histamine and other inflammatory mediators that cause bronchoconstriction and the recruitment of immune cells to the airway (109).

Detailed explanation-2: -How Airways Narrow. During an asthma attack, the smooth muscle layer goes into spasm, narrowing the airway. The middle layer swells because of inflammation, and excessive mucus is produced. In some segments of the airway, mucus forms plugs that nearly or completely block the airway.

Detailed explanation-3: -During an asthma episode or attack, the sides of the airways in your lungs swell, and the airways shrink. Less air gets in and out of your lungs, and mucus clogs up the airways even more. Severe asthma attacks can be life-threatening.