THORAX ABDOMEN AND PELVIS

Detailed explanation-1: -The main source of renin is the juxtaglomerular cells (JGCs), which release renin from storage granules. Besides the renin-angiotensin system (RAS) in the JGCs, there exist local RASs in various tissues.

Detailed explanation-2: -Renin is the first and rate-limiting step of the renin-angiotensin system. The exclusive source of renin in the circulation are the juxtaglomerular cells of the kidney, which line the afferent arterioles at the entrance of the glomeruli. Normally, renin production by these cells suffices to maintain homeostasis.

Detailed explanation-3: -Juxtaglomerular cells are responsible for the production, storage, and release of a hormone called renin which regulates blood pressure. They are also called granular cells as they have a large amount of renin-secreting granules. They sense the blood pressure in the arteriole and release an adequate amount of renin.

Detailed explanation-4: -Renin is released into your bloodstream when your blood pressure drops too low or when there’s not enough sodium in your body. Specifically, renin secretion happens when: Baroreceptors (pressure-sensitive receptors) in your arterial vessels detect low blood pressure. Your kidneys detect low salt (sodium) levels.