ANATOMY

Detailed explanation-1: -Mast cells in the presence of SCF produce predominantly pro-inflammatory cytokines, whereas when used together with SCF and IL-4, they produce mostly Th2 cytokines [61].

Detailed explanation-2: -Too many mast cells are produced and build up in tissues and body organs, releasing substances such as histamine, leukotrienes and cytokines that cause inflammation and symptoms.

Detailed explanation-3: -Mast cells are key players in the inflammatory response as they can be activated to release a wide variety of inflammatory mediators, by many different antigens including allergens, pathogens and physiological mediators.

Detailed explanation-4: -A type of white blood cell that is found in connective tissues all through the body, especially under the skin, near blood vessels and lymph vessels, in nerves, and in the lungs and intestines.

Detailed explanation-5: -Thus, via IgE-dependent degranulation, synthesis of lipid compound and cytokine/chemokine production mast cells can promote the onset of an inflammatory response favoring the influx of other cell types such as T cells and eosinophils (Galli et al., 2008b).