ANATOMY

Detailed explanation-1: -Osteoprogenitor cells differentiate from mesenchymal stem cells in bone marrow. Bone marrow can, therefore, be seen as a reservoir of osteoprogenitor cells, which differentiate further into pre-osteoblasts, which then develop into mature osteoblasts on reaching the substrate onto which bone will be deposited.

Detailed explanation-2: -Osteoprogenitor cells are the ‘stem’ cells of bone, and are the source of new osteoblasts. Osteoblasts, lining the surface of bone, secrete collagen and the organic matrix of bone (osteoid), which becomes calcified soon after it has been deposited. As they become trapped in the organic matrix, they become osteocytes.

Detailed explanation-3: -Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into osteoblasts, adipocytes, or chondrocytes, and have become the favorite source of cell-based therapy.

Detailed explanation-4: -Osteoprogenitor cells, also known as osteogenic cells, are stem cells in the bone that play a prodigal role in bone repair and growth. These cells are the precursors to the more specialized bone cells (osteocytes and osteoblasts) and reside in the bone marrow.

Detailed explanation-5: -’ These cellular units will then develop into skeletal and other tissues, such as cartilage, tendon, ligament and muscle tissue. Osteoprogenitor cell condensations can aggregate, dissipate or condense depending on the signals present, however these still remain largely unknown.