ANATOMY

Detailed explanation-1: -Bones grow in length at the epiphyseal plate by a process that is similar to endochondral ossification. The cartilage in the region of the epiphyseal plate next to the epiphysis continues to grow by mitosis. The chondrocytes, in the region next to the diaphysis, age and degenerate.

Detailed explanation-2: -Abstract. The epiphyseal growth plate is the main site of longitudinal growth of the long bones. At this site, cartilage is formed by the proliferation and hypertrophy of cells and synthesis of the typical extracellular matrix. The formed cartilage is then calcified, degraded, and replaced by osseous tissue.

Detailed explanation-3: -3 – Longitudinal Bone Growth: The epiphyseal plate is responsible for longitudinal bone growth. The proliferative zone is the next layer toward the diaphysis and contains stacks of slightly larger chondrocytes. It makes new chondrocytes (via mitosis) to replace those that die at the diaphyseal end of the plate.

Detailed explanation-4: -Bone growth in length is primarily achieved through the action of chondrocytes in the proliferative and hypertrophic zones of the growth plate. Longitudinal growth is controlled by systemic, local paracrine and local mechanical factors.

Detailed explanation-5: -The growth of the epiphyseal plate which adds to the length of bone is called interstitial growth. The epiphyseal plate is a plate of cartilage tissue that will grow in length, and will eventually be replaced by bone tissue. This is the main site for lengthening of long bones.