ANATOMY

Detailed explanation-1: -Most kidney diseases attack the nephrons, causing them to lose their filtering capacity. Damage to the nephrons may happen quickly, often as the result of injury or poisoning. But most kidney diseases destroy the nephrons slowly and silently. Only after years or even decades will the damage become apparent.

Detailed explanation-2: -Chronic kidney disease, also known as chronic renal disease or CKD, is a condition characterized by a gradual loss of kidney function over time.

Detailed explanation-3: -Chronic kidney disease is a disease characterized by progressive damage and loss of function in the kidneys. It’s estimated that chronic kidney disease affects about one in seven American adults.

Detailed explanation-4: -Given the large margin for salt handling, the ability to compensate can remain until about 90% of the nephrons are lost.