ANATOMY

Detailed explanation-1: -Antidiuretic hormone (ADH) is a chemical produced in the brain that causes the kidneys to release less water, decreasing the amount of urine produced. A high ADH level causes the body to produce less urine. A low level results in greater urine production.

Detailed explanation-2: -ADH enables the kidneys to retain water in the body. The hormone is produced in a region of the brain called the hypothalamus. It is stored and released from the pituitary gland, a small gland at the base of the brain. When diabetes insipidus is caused by a lack of ADH, it is called central diabetes insipidus.

Detailed explanation-3: -ADH is a small peptide secreted by the posterior pituitary gland. There are two major stimuli for ADH release: elevated plasma osmolality and decreased effective circulating volume. Increased plasma osmolality causes shrinkage of a specialized group of cells in the hypothalamus called osmoreceptors.

Detailed explanation-4: -ADH is released by the pituitary gland when the blood is too concentrated and it causes the kidney tubules to become more permeable . This allows more water to be reabsorbed back into the blood during selective reabsorption.

Detailed explanation-5: -As a result, the reabsorption of water from the glomerular filtrate is increased. When someone drinks lots of water, requirement of absorption of water decreases, so ADH release is suppressed.