ANATOMY
MUSCULOSKELETAL AND SOFT TISSUE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Cortisol
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Calcitonin
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Estrogen
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None of the above
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Detailed explanation-1: -The main effect of estrogen is to inhibit bone remodeling, likely via the osteocyte.
Detailed explanation-2: -Estrogen deficiency reduces the suppression of RANKL expression by bone lining cells, leading to increased osteoclastic bone resorption. Estradiol may also regulate OPG expression in bone lining cells. Bone remodeling starts with the resorption of a given quantity of bone by osteoclasts.
Detailed explanation-3: -During bone growth estrogen is needed for proper closure of epiphyseal growth plates both in females and in males. Also in young skeleton estrogen deficiency leads to increased osteoclast formation and enhanced bone resorption. In menopause estrogen deficiency induces cancellous as well as cortical bone loss.