BIOLOGY
AMINO ACIDS
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Question
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Aspartate residues are found in the active sites of many enzymes. The pKa for the beta-carboxylate of aspartate is 3.86. At physiological pH this group can function as:
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a nucleophile and a conjugate acid.
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an electrophile and a conjugate acid.
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a nucleophile and a conjugate base.
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an electrophile and a conjugate base.
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Explanation:
Detailed explanation-1: -Aspartic acid helps every cell in the body work. It plays a role in: Hormone production and release. Normal nervous system function.
Detailed explanation-2: -Aspartic acid, like glutamic acid, is classified as an acidic amino acid, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment, and could be as high as 14.
Detailed explanation-3: -Arginine-Amino acid often used at the active sites of enzymes.
Detailed explanation-4: -The three pKa values of aspartic acid are 1.89, 3.65 and 9.60.
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