BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Instead, an enzyme changes shape slightly when it binds its substrate, resulting in an even tighter fit. This adjustment of the enzyme to snugly fit the substrate is called induced fit. Illustration of the induced fit model of enzyme catalysis.

Detailed explanation-2: -The induced-fit model was first proposed by Koshland in 1958 to explain the protein conformational changes in the binding process. This model suggests that an enzyme, when binding with its substrate, optimizes the interface through physical interactions to form the final complex structure.

Detailed explanation-3: -The lock and key model states that the active site of an enzyme precisely fits a specific substrate. The induced fit model states that the active site of an enzyme will undergo a conformational change when binding a substrate, to improve the fit.

Detailed explanation-4: -The place where an enzyme binds onto the substrate is called an active site. A substrate is the molecule that enzyme acts upon. There are two theories that describe the binding of enzymes: 1) Lock and Key Theory and 2) Induced Fit Theory.