BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Substrates bind to the active site of the enzyme through hydrogen bonds, hydrophobic interactions, ionic bonding, temporary covalent interactions (Van der Waals’) or a combination of all of these to form the enzyme-substrate complex.

Detailed explanation-2: -The substrate binds to the enzyme by interacting with amino acids in the binding site. The binding site on enzymes is often referred to as the active site because it contains amino acids that both bind the substrate and aid in its conversion to product.

Detailed explanation-3: -Substrates initially bind to the active site by noncovalent interactions, including hydrogen bonds, ionic bonds, and hydrophobic interactions. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction.