BIOMOLECULES AND ENZYMES

BIOLOGY

ENZYMES

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
As food travels through the digestive system, it is exposed to a variety of pH levels. The stomach has a pH of 2 due to the presence of hydrochloric acid (HCl), and the small intestine has a pH ranging from 7 to 9. HCl converts pepsinogen into pepsin, an enzyme that digests proteins in the stomach. Which of the following most likely happens to pepsin as it enters the small intestine?
A
It becomes inactive.
B
It begins to replicate.
C
It’s shape changes to engulf large proteins.
D
It’s activity increases to digest more proteins.
Explanation: 

Detailed explanation-1: -The intraluminal pH is rapidly changed from highly acid in the stomach to about pH 6 in the duodenum. The pH gradually increases in the small intestine from pH 6 to about pH 7.4 in the terminal ileum. The pH drops to 5.7 in the caecum, but again gradually increases, reaching pH 6.7 in the rectum.

Detailed explanation-2: -Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.

Detailed explanation-3: -Different organs function at their optimal level of pH. For example, the enzyme pepsin requires low pH to act and break down food, while the enzymes in intestine require high pH or alkaline environment to function. Similarly, any increase or decrease in the blood pH can lead to several disorders.

Detailed explanation-4: -But the stomach requires a very acidic pH of 1.5 to 2.5 to maintain digestive health (see below). The pH of our stomach is critical to the digestion of many nutrients and acts as the first line of defense against harmful bacteria and viruses.

There is 1 question to complete.