BIOLOGY
HORMONES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They absorb glucose and convert it to glycogen
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They absorb glucose and convert it to glucagon
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They break down glucagon and release the glucose into the blood
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They break down glycogen and release the glucose into the blood
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They release glucagon into the blood
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Detailed explanation-1: -A spike in insulin signals the liver that a person’s blood glucose level is also high, causing the liver to absorb glucose and change it into glycogen.
Detailed explanation-2: -In the fed state, glucose enters hepatocytes via GLUT2 and is phosphorylated by glucokinase and used to synthesize glycogen by glycogen synthase (4). In the fasted state, glycogen is hydrolyzed by glycogen phosphorylase to generate glucose (glycogenolysis) (Fig.
Detailed explanation-3: -In liver: Insulin promotes glucose uptake in liver, but not directly. Insulin promotes uptake by increasing phosphorylation (trapping) and utilization of glucose.
Detailed explanation-4: -The liver both stores and manufactures glucose depending upon the body’s need. The need to store or release glucose is primarily signaled by the hormones insulin and glucagon. During a meal, your liver will store sugar, or glucose, as glycogen for a later time when your body needs it.
Detailed explanation-5: -The liver receives dietary carbohydrates directly from the intestine via the portal vein. Glucokinase phosphorylates glucose to glucose 6-phosphate inside the hepatocyte, ensuring that an adequate flow of glucose enters the cell to be metabolized. Glucose 6-phosphate may proceed to several metabolic pathways.