BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Senescence (/sɪˈnɛsəns/) or biological aging is the gradual deterioration of functional characteristics in living organisms.

Detailed explanation-2: -The process of growing old. In biology, senescence is a process by which a cell ages and permanently stops dividing but does not die. Over time, large numbers of old (or senescent) cells can build up in tissues throughout the body.

Detailed explanation-3: -There are two types of cell senescence. One is replicative senescence, which relies on telomere length-dependent limit of cell divisions. The second is stress-induced premature senescence (SIPS) which is telomere-independent. Cell senescence is a barrier to cancer.

Detailed explanation-4: -Characteristics of senescent cells Senescent cells are characterised by flattened and enlarged morphology. They exhibit several molecular markers, including telomere-dysfunction-induced foci, senescence-associated heterochromatin foci (SAHF), lipofuscin granules, DNA scars, altered gene expression (5, 7).

Detailed explanation-5: -There are some common examples of senescence that most people experience as they age. For example, wrinkles are a very normal part of getting older, as is worsening eyesight and hearing. These are a part of the normal senescence that is happening in a person’s body.