BIOMOLECULES AND ENZYMES

BIOLOGY

NUCLEIC ACIDS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The chaperonin protein has been exposed to a lower pH than it is adapted for. What might occur because of this?
A
the chaperonin would do it job of aiding protein folding
B
the protein would denature, therefore not allowing the chaperonin to complete its function
C
the lipids in the chaperonin would denature
D
the DNA in the chaperonin would tell it to go to slepp
Explanation: 

Detailed explanation-1: -while decreasing the pH by adding acids converts the-COO-ion to-COOH group. These changes prohibit the ionic attraction between the side chains, i.e. salt bridges, resulting in the unfolding of proteins.

Detailed explanation-2: -Chaperones are proteins that guide proteins along the proper pathways for folding. They protect proteins when they are in the process of folding, shielding them from other proteins that might bind and hinder the process.

Detailed explanation-3: -Protein denaturation due to pH The ionizable groups in amino acids are able to become ionized when changes in pH occur. A pH change to more acidic or more basic conditions can induce unfolding. Acid-induced unfolding often occurs between pH 2 and 5, base-induced unfolding usually requires pH 10 or higher.

Detailed explanation-4: -In response to the appearance of damaged proteins, cells induce the expression of heat shock proteins. These can function as molecular chaperones to prevent protein aggregation and to keep proteins in a state competent for either refolding or degradation.

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