BIOLOGY
NUCLEIC ACIDS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Ligase
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Helicase
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DNA Polymerase 1
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DNA Polymerase 3
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Detailed explanation-1: -DNA ligases are best known for their role in joining adjacent Okazaki fragments at the lagging strand of the replication fork; however, they are essentially involved in any process that requires sealing of phosphodiester bonds from the DNA backbone.
Detailed explanation-2: -The enzyme DNA ligase joins these fragments to produce a single, continuous strand of DNA. It does so by creating bonds called phosphodiester bonds between the sugar and phosphate groups of nucleotides on adjacent fragments.
Detailed explanation-3: -DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates.