BIOLOGY
STRUCTURE OF PROTEINS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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form barriers along the outside of the protein
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fold inward during folding when placed in aqueous environments
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be involved in forming active sites
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None of the above
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Detailed explanation-1: -A Hydrophobic Effect. The major driving force in protein folding is the hydrophobic effect. This is the tendency for hydrophobic molecules to isolate themselves from contact with water. As a consequence during protein folding the hydrophobic side chains become buried in the interior of the protein.
Detailed explanation-2: -The arrangement of hydrophobic and hydrophilic side chains in a protein determines its folded structure. Because of the hydrophobic effect, hydrophobic side chains (purple) are sequestered to the protein’s interior when it folds. Hydrophilic side chains (green) are usually left exposed on the protein’s surface.
Detailed explanation-3: -hydrophobic-hydrophilic (HP) interactions happen when a protein is folding into its tertiary structure. The amino acids with hydrophobic side chains move to the core of the protein to be away from water, and the hydrophilic side chains move towards the outside of the protein because they have an affinity with water.
Detailed explanation-4: -On folding, hydrophobic amino acids get buried inside the protein such that they are shielded from the water; this hydrophobic effect makes a protein fold stable.