BIOLOGY
STRUCTURE OF PROTEINS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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deletion frameshift
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insertion frameshift
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substitution
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nonsense
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Detailed explanation-1: -Listen to pronunciation. (FRAYM-shift myoo-TAY-shun) An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.
Detailed explanation-2: -Frameshift mutations are among the most deleterious changes to the coding sequence of a protein.
Detailed explanation-3: -Frameshift mutations by insertion or deletion (fsindels) are suggested to induce more immunogenic tumor-specific neoantigens, conferring better response to ICIs. Positive correlation of fsindels with ICI response has been studied in melanoma and renal cell carcinoma.
Detailed explanation-4: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.