BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Niacin can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations of niacin have been linked to clinically apparent, acute liver injury which can be severe as well as fatal.

Detailed explanation-2: -Serious side effects are most likely if you take between 2, 000 to 6, 000 mg of niacin a day. If you think you might have overdosed on niacin, seek medical attention immediately. If you have liver disease, peptic ulcer disease or severe low blood pressure (hypotension), don’t take large amounts of niacin.

Detailed explanation-3: -Because niacin has also been linked to liver damage and strokes, most doctors now recommend it only for people who can’t take statins to treat high triglyceride levels. If you’re concerned about taking niacin, talk to your doctor.

Detailed explanation-4: -However, at high doses of 500 mg/day or more, nicotinamide can cause diarrhea, easy bruising, and can increase bleeding from wounds. Even higher doses of 3, 000 mg/day or more can cause nausea, vomiting, and liver damage.