MEDICINE
CARDIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Protein S
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Protein C
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tissue factor pathway inhibitor
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Nitric oxide
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prostacyclin
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Detailed explanation-1: -Thrombin is a proteolytic enzyme derived from PT, which aids in the process of forming blood clots by catalyzing the conversion of Fib to fibrin.
Detailed explanation-2: -Tissue factor (TF) is a transmembrane receptor for Factor VII/VIIa (FVII/VIIa). It is constitutively expressed by cells surrounding blood vessels. The endothelium physically separates this potent “activator” from its circulating ligand FVII/FVIIa and prevents inappropriate activation of the clotting cascade.
Detailed explanation-3: -The common pathway factors X, V, II, I, and XIII are also known as Stuart-Prower factor, proaccelerin, prothrombin, fibrinogen, and fibrin-stabilizing factor, respectively. Clotting factor IV is a calcium ion that plays an important role in all 3 pathways.
Detailed explanation-4: -It is now known that TFPI dampens the blood coagulation pathway by blocking the activity of 2 of the major protease–cofactor complexes, TF–fVIIa13 and prothrombinase (Figure A).