CLINICAL MEDICINE

MEDICINE

CARDIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
It plays a fundamental role in the control and termination of the coagulation process, with a double effect: it binds complete TF/factor Vlla and directly inhibits factor Xa.
A
Protein S
B
Protein C
C
tissue factor pathway inhibitor
D
Nitric oxide
E
prostacyclin
Explanation: 

Detailed explanation-1: -Thrombin is a proteolytic enzyme derived from PT, which aids in the process of forming blood clots by catalyzing the conversion of Fib to fibrin.

Detailed explanation-2: -Tissue factor (TF) is a transmembrane receptor for Factor VII/VIIa (FVII/VIIa). It is constitutively expressed by cells surrounding blood vessels. The endothelium physically separates this potent “activator” from its circulating ligand FVII/FVIIa and prevents inappropriate activation of the clotting cascade.

Detailed explanation-3: -The common pathway factors X, V, II, I, and XIII are also known as Stuart-Prower factor, proaccelerin, prothrombin, fibrinogen, and fibrin-stabilizing factor, respectively. Clotting factor IV is a calcium ion that plays an important role in all 3 pathways.

Detailed explanation-4: -It is now known that TFPI dampens the blood coagulation pathway by blocking the activity of 2 of the major protease–cofactor complexes, TF–fVIIa13 and prothrombinase (Figure A).

There is 1 question to complete.