CLINICAL MEDICINE

Detailed explanation-1: -Interleukin-33 is a cytokine that is secreted, when epithelial cells are exposed to pathogens, allergens, or injury. Other than targeting various immune cells during inflammation, IL-33 also targets hematopoietic stem and progenitor cells to promote myelopoiesis and myeloid cell migration [20].

Detailed explanation-2: -Proinflammatory cytokines, including TNF-, IL-1, IL-6, and IL-17, are intrinsic factors, and they promote the migration, proliferation, and differentiation via both autocrine and paracrine ways.

Detailed explanation-3: -Interleukin-6 (IL-6) is a multifunctional cytokine that plays a central role in host defense due to its wide range of immune and hematopoietic activities and its potent ability to induce the acute phase response.

Detailed explanation-4: -Hematopoietic cytokines are large family of extracellular ligands that stimulate hematopoietic cells to differentiate into eight principle types of blood cells. Numerous cytokines are involved in the regulation of hematopoiesis within a complex network of positive and negative regulators.