CLINICAL MEDICINE

Detailed explanation-1: -HbA, the most common adult form of hemoglobin, comprises two alpha and two beta-globin subunits. Inversely to HbF, HbA production explodes after birth and ultimately makes up 95-98% of hemoglobin in adults.

Detailed explanation-2: -Normal Results In adults, these are normal percentages of different hemoglobin molecules: HbA: 95% to 98% (0.95 to 0.98) HbA2: 2% to 3% (0.02 to 0.03) HbE: Absent.

Detailed explanation-3: -Hemoglobin A (HbA), also known as adult hemoglobin, hemoglobin A1 or 22, is the most common human hemoglobin tetramer, accounting for over 97% of the total red blood cell hemoglobin. Hemoglobin is an oxygen-binding protein, found in erythrocytes, which transports oxygen from the lungs to the tissues.

Detailed explanation-4: -HbA2, composing of two chains and two chains, is a minor component of the hemoglobin present in normal adult red blood cells, accounting for about 2.5% of the total hemoglobin in healthy individuals. However, HbA2 level is also elevated in some pregnant women.

Detailed explanation-5: -Hemoglobin A0 is prepared from lysed human blood cells by sequential ion-exchange. It is a mixture of non-glycated and glycated hemoglobin A0 fractions, but is essentially free of HbA1a, HbA1b, HbA1c and HbF.