CLINICAL MEDICINE

MEDICINE

ENDOCRINOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Are lipid molecules that have cholesterol as a common precursor
A
Steroids
B
Amines
C
Peptides and Proteins
D
None of the above
Explanation: 

Detailed explanation-1: -Steroids are lipids because they are hydrophobic and insoluble in water, but they do not resemble lipids since they have a structure composed of four fused rings. Cholesterol is the most common steroid and is the precursor to vitamin D, testosterone, estrogen, progesterone, aldosterone, cortisol, and bile salts.

Detailed explanation-2: -Cholesterol is also the precursor of all steroid hormones and bile acids and plays important roles in membrane trafficking, transmembrane signaling processes as well as cell proliferation (Goedeke & Fernandez-Hernando 2012).

Detailed explanation-3: -Cholesterol is the sole precursor of steroids. Steroid synthesis is initiated at the inner mitochondrial membrane (IMM), where the cytochrome P450 cholesterol side chain cleavage enzyme (CYP11A1) catalyzes the conversion of cholesterol to pregnenolone [1].

Detailed explanation-4: -Cholesterol belongs to the steroid family of lipid (fat) compounds. It’s a type of fat in your body and several of the foods you eat. While too much cholesterol isn’t a good thing, the body needs some cholesterol to run at its best. Cholesterol is the most abundant steroid in the body.

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