CLINICAL MEDICINE

MEDICINE

ENDOCRINOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Decreased thyroid secretion greatly increases the plasma levels of cholesterol, phospholipids, and triglycerides
A
TRUE
B
FALSE
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -When someone is affected by hypothyroidism, their metabolism is decreased, including the breakdown of cholesterol and triglycerides. This leads to elevated levels of those fatty substances in the bloodstream, which puts patients at risk of cardiovascular disease.

Detailed explanation-2: -Thyroid hormone has a direct effect on cholesterol levels. Hypothyroid patients have increased cholesterol levels compared to individuals with normal thyroid function. Treatment with thyroid hormone often lowers the cholesterol levels in patients with hypothyroidism.

Detailed explanation-3: -Thyroid Hormone Reduces Cholesterol via a Non-LDL Receptor-Mediated Pathway-PMC.

Detailed explanation-4: -Thyroid hormone is known to play a role in regulating the synthesis, metabolism, and mobilization of lipids. In patients with overt hypothyroidism there is an increase in serum total cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B, lipoprotein(a) levels, and possibly triglyceride levels.

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