CLINICAL MEDICINE

Detailed explanation-1: -Insulin is kept inside miniature membrane-bound storage compartments known as secretory granules (SGs), and these specialized organelles can readily fuse with the plasma membrane upon cellular stimulation to release insulin.

Detailed explanation-2: -The secretory pathway in neuroendocrine cells, exocrine cells, peptidergic neurons, mast cells, and other secretory cells that store proteins has an additional process that concentrates specific proteins into secretory granules.

Detailed explanation-3: -Secretory granules are specialized intracellular organelles that serve as a storage pool for selected secretory products.

Detailed explanation-4: -The secretory pathway occurs in a vectorial manner and begins with uptake of amino acids that are used by the rough endoplasmic reticulum to produce newly synthesized proteins. These new proteins are transported to the Golgi complex for further processing and sorting.