CLINICAL MEDICINE

Detailed explanation-1: -Prealbumin. Prealbumin, also known as thyroxine-binding prealbumin, or transthyretin, is a sensitive marker for assessing the severity of illness in children who have critical or chronic disease, and correlates with outcomes and recovery.

Detailed explanation-2: -TTR, formerly known as thyroxine-binding prealbumin, is a 55 kDa, highly acidic tetramer devoid of carbohydrate. It forms a complex with retinol-binding protein (RBP) and thus plays a role in the transport of vitamin A.

Detailed explanation-3: -Abstract. Transthyretin (TTR) was previously called prealbumin because the band it formed on agarose gel electrophoresis at pH 8.6 was at the prealbumin position.

Detailed explanation-4: -Prealbumin, also called transthyretin, is one of the major proteins in the blood and is produced primarily by the liver. Its functions are to carry thyroxine (the main thyroid hormone) and vitamin A throughout the body.

Detailed explanation-5: -TTR was originally called prealbumin (or thyroxine-binding prealbumin) because it migrated faster than albumin on electrophoresis gels. Prealbumin was felt to be a misleading name, it is not a synthetic precursor of albumin. The alternative name TTR was proposed by DeWitt Goodman in 1981.