CLINICAL MEDICINE

Detailed explanation-1: -CD4 and CD8 co-receptors on the surface of T cells. Cytotoxic T cells (TC) express CD8, which recognizes class I MHC proteins, whereas helper T cells (TH) express CD4, which recognizes class II MHC proteins.

Detailed explanation-2: -Cytotoxic T cells recognize antigen bound to MHC protein type 1.

Detailed explanation-3: -It is well established that major histocompatibility complex (MHC) class I and class II molecules are recognized by CD8+ and CD4+ T lymphocytes, respectively.

Detailed explanation-4: -The surface of a cytotoxic T-cell has something called a CD8 receptor. The CD8 receptor interacts with cells called major histocompatibility complex (MHC) Class I molecules to recognize when healthy cells are infected. When the CD8 receptor recognizes an infected cell, it activates the cytotoxic T-cells.

Detailed explanation-5: -MHC class I molecules present peptides derived from intracellular protein, to CD8 T-lymphocyte receptors and induce the cytotoxic T-lymphocyte response. They are important for clearing intra-cellular pathogens.