CLINICAL MEDICINE

Detailed explanation-1: -Mechanical barriers physically block pathogens from entering the body. The skin is the most important mechanical barrier. In fact, it is the single most important defense the body has. The outer layer of the skin is tough and very difficult for pathogens to penetrate.

Detailed explanation-2: -Skin is a barrier that serves as one of the body’s first lines of defense against harmful microbes. Specialized immune cells within skin tissue help to fight invading organisms.

Detailed explanation-3: -The epithelial surfaces of the body keep pathogens out, and protect against colonization and against viruses and bacteria that enter through specialized cell-surface interactions, by preventing pathogen adherence and by secreting antimicrobial enzymes and peptides.

Detailed explanation-4: -Microorganisms capable of causing disease-or pathogens-usually enter our bodies through the eyes, mouth, nose, or urogenital openings, or through wounds or bites that breach the skin barrier.

Detailed explanation-5: -Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi.