CLINICAL MEDICINE

Detailed explanation-1: -Death. While an infection of the variola minor virus would lead to death with a probability of less than one percent, the case fatality rate of the variola major virus has been estimated to be around 30 percent.

Detailed explanation-2: -Two forms of the disease are recognized, variola minor with a mortality rate of approximately 1%, and the more common variola major with a mortality rate of 30%. Between 65–80% of survivors are marked with deep pitted scars (pockmarks), most prominent on the face.

Detailed explanation-3: -Before 1980, around 30% of people with smallpox died from the disease. Most people who survived smallpox had severe scarring after scabs from the blisters fell off. Smallpox also caused blindness when ulcers formed on the eyes.

Detailed explanation-4: -Untreated progressive vaccinia is fatal, but treatment with VIG or the antiviral cidofovir may be effective in some cases. VIG and thiosemicarbazone treatment in the late 1960s and 1970s reduced the fatality rate for progressive vaccinia from near 100% to 33%.

Detailed explanation-5: -One of history’s deadliest diseases, smallpox is estimated to have killed more than 300 million people since 1900 alone. But a massive global vaccination campaign put an end to the disease in 1977-making it the first disease ever eradicated.